Across TCGA pan-cancer cohorts, LINC01974 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LINC01974’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC01974 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC01974 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.
KIRC and KICH are the cancer types where LINC01974 tumor–normal differential expression is most reproducible.