Across TCGA pan-cancer cohorts, LINC01946 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of LINC01946’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where LINC01946 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC01946 is over-expressed in tumor.
BRCA, KIRC, and LIHC are the cancer types where LINC01946 tumor–normal differential expression is most reproducible.