LINC01727

Across TCGA pan-cancer cohorts, LINC01727 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LINC01727’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where LINC01727 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC01727 is over-expressed in tumor, although a few such as KIRP and LIHC show the opposite, repressed pattern.

KIRP, LIHC, and LUAD are the cancer types where LINC01727 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC01727 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	All	−0.359	<.001	11	view →
LIHC	Male	All	−0.460	<.001	8	view →
LUAD	All	All	+0.125	<.001	7	view →
BRCA	All	II,III,IV	+0.087	<.001	6	view →
KIRC	Male	All	−0.202	<.001	4	view →
STAD	All	All	+0.107	.011	4	view →
KICH	All	All	−0.164	.012	3	view →
ESCA	All	All	+0.066	.021	3	view →
CHOL	All	All	−0.820	.003	2	view →
PRAD	All	All	+0.213	.001	2	view →
THCA	All	All	−0.080	.025	2	view →
HNSC	All	II,III,IV	+0.051	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LINC01727–KIRP

Open the KIRP breakdown →