Across TCGA pan-cancer cohorts, LINC01657 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LINC01657’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where LINC01657 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC01657 is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.
STAD and LUSC are the cancer types where LINC01657 tumor–normal differential expression is most reproducible.