LINC01254

Across TCGA pan-cancer cohorts, LINC01254 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of LINC01254’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LINC01254 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC01254 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

HNSC, KIRC, and BRCA are the cancer types where LINC01254 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC01254 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.276	.001	9	view →
KIRC	All	II,III,IV	−0.006	.002	8	view →
BRCA	All	All	−0.043	<.001	6	view →
LUSC	All	All	+0.132	.001	4	view →
BLCA	All	III,IV	+0.019	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

LINC01254–HNSC

Open the HNSC breakdown →