LINC00973

Across TCGA pan-cancer cohorts, LINC00973 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of LINC00973’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LINC00973 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC00973 is over-expressed in tumor, although a few such as PRAD and KICH show the opposite, repressed pattern.

HNSC, THCA, and LUAD are the cancer types where LINC00973 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00973 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.391	<.001	10	view →
THCA	All	All	+0.583	<.001	9	view →
LUAD	All	II,III,IV	+1.831	<.001	8	view →
COAD	All	All	+0.149	.006	5	view →
LUSC	All	All	+0.343	.015	3	view →
LIHC	All	All	+0.022	<.001	3	view →
PRAD	All	All	−0.025	.045	2	view →
KIRP	All	All	+0.465	.033	1	view →
KIRC	Male	All	+0.232	.049	1	view →
KICH	Female	All	−0.143	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

LINC00973–HNSC

Open the HNSC breakdown →