Across TCGA pan-cancer cohorts, LINC00917 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LINC00917’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where LINC00917 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC00917 is over-expressed in tumor, although a few such as KIRP show the opposite, repressed pattern.
COAD, THCA, and HNSC are the cancer types where LINC00917 tumor–normal differential expression is most reproducible.