Across TCGA pan-cancer cohorts, LINC00686 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of LINC00686’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC00686 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00686 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
KIRC are the cancer types where LINC00686 tumor–normal differential expression is most reproducible.