LINC00645

Across TCGA pan-cancer cohorts, LINC00645 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LINC00645’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC00645 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00645 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where LINC00645 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00645 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−3.857	<.001	12	view →
KIRP	Male	All	−3.723	<.001	11	view →
KICH	Female	II,III,IV	−3.724	<.001	8	view →
BRCA	All	II,III,IV	−0.229	<.001	8	view →
LUSC	All	All	+0.072	<.001	6	view →
LUAD	All	All	+0.025	.006	5	view →
LIHC	All	All	+0.019	.016	4	view →
HNSC	Female	II,III,IV	+0.030	.003	3	view →
UCEC	All	All	+0.739	.024	2	view →
BLCA	Male	IV	−0.022	.038	1	view →
CHOL	All	All	+0.011	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

LINC00645–KIRC

Open the KIRC breakdown →