LINC00589

Across TCGA pan-cancer cohorts, LINC00589 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of LINC00589’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LINC00589 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC00589 is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.

THCA, KIRC, and LUAD are the cancer types where LINC00589 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00589 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	III,IV	+0.110	<.001	9	view →
KIRC	Male	All	+0.094	<.001	8	view →
LUAD	Male	All	+0.528	<.001	4	view →
KIRP	Male	All	+0.056	<.001	4	view →
STAD	Male	All	+0.229	.007	2	view →
BRCA	Female	All	+0.210	.032	2	view →
KICH	All	All	+0.110	.004	2	view →
PRAD	All	All	−0.057	.023	2	view →
COAD	All	All	+0.254	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

LINC00589–THCA

Open the THCA breakdown →