LINC00574

Across TCGA patient cohorts, LINC00574 mutation is significantly associated with the RNA expression of many other genes, with 686 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LINC00574-associated genes across cancer lineages are HMGXB4, GNPNAT1, and DHODH. Each is linked with LINC00574 in more than 1 cancer types. Because this analysis shows association rather than direction, both LINC00574-to-partner and partner-to-LINC00574 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGXB4 grouped by LINC00574-low versus LINC00574-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINC00574→partner) and Y-score (partner→LINC00574) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMGXB4 →	+0.587	+3.470	.008	.003	3	1
UCEC	GNPNAT1 →	+0.772	+3.491	.004	.002	3	1
UCEC	DHODH →	+0.532	+3.362	<.001	.005	3	1
UCEC	CMC2 →	+0.473	+3.387	.003	.004	3	1
UCEC	HSDL1 →	+0.588	+3.459	.003	.005	3	1
UCEC	BLOC1S6 →	+0.617	+3.470	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 686 associations by consensus.

HMGXB4 by LINC00574 expression — UCEC

Explore this box plot interactively →