LINC00574

Across TCGA patient cohorts, LINC00574 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LINC00574-associated genes across cancer lineages are Heregulin, JNK_pT183_Y185, and Ku80. Each is linked with LINC00574 in more than 1 cancer types. Because this analysis shows association rather than direction, both LINC00574-to-partner and partner-to-LINC00574 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by LINC00574-low versus LINC00574-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINC00574→partner) and Y-score (partner→LINC00574) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.180	-3.000	.007	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.208	-3.156	.024	.020	3	1
UCEC	Ku80 →	+0.299	+3.183	.021	.010	3	1
UCEC	STAT3_pY705 →	-0.465	-3.169	.001	.020	3	1
UCEC	4E-BP1 →	+0.366	+2.837	.013	.035	2	1
UCEC	EGFR_pY1068 →	-0.362	-3.169	.008	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Heregulin by LINC00574 expression — UCEC

Explore this box plot interactively →