long intergenic non-protein coding RNA 558Genealiases: []
Q-omics provides the consensus-scored LINC00558 profile across patient tissues and cancer cell-line models. LINC00558 expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, LINC00558 is differentially expressed in 2, with the highest sampling consensus in HNSC. Additionally, LINC00558 RNA expression shows 6,106 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight UCEC, HNSC, and STAD as cancer lineages where LINC00558 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LINC00558 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LINC00558 survival associations across molecular data types. LINC00558 RNA expression shows survival associations in the most cancer types (16). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LINC00558 RNA expression–survival associations across cancer types. High LINC00558 expression shows unfavorable associations in UCEC, COAD, CESC, UCS, LUAD and SARC. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify UCEC as the clearest survival context for LINC00558 RNA expression.
This table summarizes LINC00558 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for LINC00558. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LINC00558 shows higher tumor expression in HNSC and PRAD. The HNSC box plot shows higher LINC00558 RNA expression in tumor versus normal tissue (log2 FC = +0.009, t-test p = .031).
This table shows molecular features associated with LINC00558 in patient tissues and cancer cell lines. In patient samples, LINC00558 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
