LINC00494

Across TCGA pan-cancer cohorts, LINC00494 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LINC00494’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LINC00494 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00494 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, HNSC, and KIRP are the cancer types where LINC00494 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00494 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.206	<.001	8	view →
HNSC	All	III,IV	+0.097	.016	7	view →
KIRP	All	All	+1.245	<.001	6	view →
BRCA	All	II,III,IV	+0.143	.001	6	view →
STAD	All	All	+0.538	.004	4	view →
ESCA	All	All	+0.788	.016	3	view →
KIRC	All	All	+0.359	.007	3	view →
LUAD	Female	All	+0.233	.005	3	view →
CHOL	All	All	+2.217	.005	2	view →
KICH	Female	All	−0.629	.013	2	view →
PAAD	Male	All	−0.199	.046	2	view →
THCA	All	All	−0.196	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LINC00494–COAD

Open the COAD breakdown →