Across TCGA pan-cancer cohorts, LINC00488 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LINC00488’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where LINC00488 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00488 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.
KICH, COAD, and KIRC are the cancer types where LINC00488 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00488 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.