Q-omics provides the consensus-scored LINC00461 profile across patient tissues and cancer cell-line models. LINC00461 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, LINC00461 is differentially expressed in 14, with the highest sampling consensus in KIRC. Additionally, LINC00461 RNA expression shows 13,529 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRC, and GBM as cancer lineages where LINC00461 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LINC00461 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LINC00461 survival associations across molecular data types. LINC00461 RNA expression shows survival associations in the most cancer types (20), followed by mutation status (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LINC00461 RNA expression–survival associations across cancer types. High LINC00461 expression shows unfavorable associations in KIRC, ACC, BRCA, UVM and COAD, but favorable associations in PAAD. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for LINC00461 RNA expression.
This table summarizes LINC00461 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for LINC00461. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LINC00461 shows lower tumor expression in KIRC, COAD, KIRP, THCA and KICH and higher tumor expression in HNSC. The KIRC box plot shows higher LINC00461 RNA expression in normal versus tumor tissue (log2 FC = −0.626, t-test p < 0.001).
This table shows molecular features associated with LINC00461 in patient tissues and cancer cell lines. In patient samples, LINC00461 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.
