LINC00445

Across TCGA pan-cancer cohorts, LINC00445 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of LINC00445’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where LINC00445 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00445 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

BRCA, LUSC, and KICH are the cancer types where LINC00445 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00445 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	II,III,IV	−0.965	<.001	6	view →
LUSC	All	All	+0.036	.010	4	view →
KICH	All	All	+0.467	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

LINC00445–BRCA

Open the BRCA breakdown →