LINC00443

Across TCGA patient cohorts, LINC00443 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,650 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible LINC00443-associated GO terms across cancer lineages are ER-nucleus signaling pathway, Regulation of small GTPase mediated signal transduction, and Regulation of actin filament organization. Each is linked with LINC00443 in more than 16 cancer types. Because this analysis shows association rather than direction, both LINC00443-to-partner and partner-to-LINC00443 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-nucleus signaling pathway grouped by LINC00443-low versus LINC00443-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LINC00443→partner) and Y-score (partner→LINC00443) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	ER-nucleus signaling pathway →	+0.041	+0.508	.002	.002	3	17
STAD	Regulation of small GTPase mediated signal transduction →	+0.030	+0.530	<.001	.001	3	14
THYM	Regulation of actin filament organization →	+0.025	+0.024	.004	.001	3	13
ESCA	Tissue homeostasis →	+0.031	+0.682	<.001	<.001	3	13
ESCA	Response to growth hormone →	+0.044	+0.610	<.001	<.001	3	12
STAD	Response to endoplasmic reticulum stress →	+0.029	+0.418	<.001	.004	1	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,650 associations by consensus.

ER-nucleus signaling pathway by LINC00443 expression — ESCA

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