Across TCGA pan-cancer cohorts, LINC00349 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LINC00349’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where LINC00349 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00349 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.
KICH and KIRP are the cancer types where LINC00349 tumor–normal differential expression is most reproducible.