LINC00251

Across TCGA pan-cancer cohorts, LINC00251 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated LINC00251 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher LINC00251 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LINC00251 expression acts as an unfavorable survival marker, although some lineages such as LUAD and DLBC show a favorable association.

SKCM, KIRP, and STAD are the cancer types where LINC00251 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.650	0.875	.002	96	view →
KIRP	OS	Tertile	II,III,IV	0.180	0.782	<.001	75	view →
STAD	DFS	Tertile	All	0.205	0.424	.004	63	view →
KIRC	OS	Tertile	All	0.711	0.812	.013	30	view →
READ	DFS	Tertile	IV	0.082	0.619	.001	27	view →
LUAD	DFS	Tertile	All	0.847	0.762	.009	20	view →
UCS	DFS	Tertile	All	0.184	0.528	.043	18	view →
LUSC	OS	Tertile	III,IV	0.112	0.663	.041	18	view →
ESCA	DFS	Tertile	All	0.148	0.673	.040	18	view →
THYM	DFS	Tertile	All	0.265	0.778	.005	15	view →
TGCT	DFS	Quartile	II,III,IV	0.587	1.000	.011	10	view →
DLBC	DFS	Median	III,IV	0.871	0.373	.026	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

LINC00251–SKCM (OS)

Open the SKCM breakdown →