Across TCGA pan-cancer cohorts, LINC00222 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of LINC00222’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LINC00222 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC00222 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.
HNSC, KIRC, and BRCA are the cancer types where LINC00222 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00222 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.