Across TCGA pan-cancer cohorts, LINC00200 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LINC00200’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where LINC00200 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC00200 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.
LIHC, KIRC, and COAD are the cancer types where LINC00200 tumor–normal differential expression is most reproducible.