LIN54

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, LIN54 mutation is significantly associated with the RNA expression of many other genes, with 2,787 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIN54-associated genes across cancer lineages are MIR4478, RNU6-442P, and PPP1R12BP1. Each is linked with LIN54 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIN54-to-partner and partner-to-LIN54 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN54→partner) and Y-score (partner→LIN54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CESCMIR4478 →+1.413+3.996<.001.00532
CESCRNU6-442P →+0.183+4.757<.001.00432
CESCPPP1R12BP1 →+0.015+4.384<.001.00832
LUSCKRTAP2-4 →+0.057+7.102<.001<.00132
BRCARNU7-130P →+0.873+5.378<.001.00632
BLCARNU5A-4P →+0.255+3.792<.001.00432
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,787 associations by consensus.

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