Across TCGA patient cohorts, LIN52 mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible LIN52-associated genes across cancer lineages are RNU6-414P, RNU6-1163P, and RNY4P3. Each is linked with LIN52 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIN52-to-partner and partner-to-LIN52 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN52→partner) and Y-score (partner→LIN52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-414P →	+0.436	+4.642	.001	.004	3	2
BLCA	RNU6-1163P →	+0.773	+6.603	<.001	<.001	3	1
BLCA	RNY4P3 →	+0.385	+4.429	.006	.006	3	1
BLCA	IGKV1OR9-1 →	+0.246	+4.680	.007	.003	3	1
BLCA	SNORA70H →	+0.549	+4.299	<.001	.007	3	1
BLCA	TRAJ4 →	+0.614	+4.331	.006	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Exploration

LIN52 survival (RNA) · tumor vs normal (RNA) · all LIN52 data types