Across TCGA pan-cancer cohorts, LIN52 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LIN52’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LIN52 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LIN52 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.
HNSC, KIRC, and KICH are the cancer types where LIN52 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LIN52 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.