LIN37

Across TCGA patient cohorts, LIN37 mutation is significantly associated with the RNA expression of many other genes, with 2,991 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIN37-associated genes across cancer lineages are LINC02559, RN7SL25P, and MIR7976. Each is linked with LIN37 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIN37-to-partner and partner-to-LIN37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02559 grouped by LIN37-low versus LIN37-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN37→partner) and Y-score (partner→LIN37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC02559 →	+0.573	+4.020	<.001	.009	3	2
CESC	RN7SL25P →	+0.193	+2.982	<.001	.009	3	2
CESC	MIR7976 →	+0.614	+3.590	<.001	.002	3	2
UCEC	OR13D3P →	+0.111	+2.130	.001	<.001	3	2
UCEC	RNU6-1029P →	+0.182	+2.123	<.001	.009	3	2
UCEC	FAR1P1 →	+0.066	+2.296	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,991 associations by consensus.

LINC02559 by LIN37 expression — CESC

Explore this box plot interactively →