LIN28A

Across TCGA patient cohorts, LIN28A RNA expression is significantly associated with the go_rna of many other GO terms, with 6,601 significant associations in total. STAD shows the largest number of these associations.

The most reproducible LIN28A-associated GO terms across cancer lineages are Telomere maintenance in response to DNA damage, Recombinational repair, and mRNA transport. Each is linked with LIN28A in more than 15 cancer types. Because this analysis shows association rather than direction, both LIN28A-to-partner and partner-to-LIN28A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomere maintenance in response to DNA damage grouped by LIN28A-low versus LIN28A-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN28A→partner) and Y-score (partner→LIN28A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Telomere maintenance in response to DNA damage →	+0.068	+0.179	<.001	<.001	3	15
STAD	Recombinational repair →	+0.068	+0.153	<.001	<.001	3	15
STAD	mRNA transport →	+0.089	+0.186	<.001	<.001	3	14
SCLC	Regulation of microtubule cytoskeleton organization →	+0.080	+0.694	<.001	.001	1	16
STAD	Regulation of DNA replication →	+0.078	+0.188	<.001	<.001	3	14
STAD	Regulation of DNA repair →	+0.075	+0.242	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,601 associations by consensus.

Telomere maintenance in response to DNA damage by LIN28A expression — STAD

Explore this box plot interactively →