LIN28A

Across TCGA pan-cancer cohorts, LIN28A RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated LIN28A data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher LIN28A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LIN28A expression acts as an unfavorable survival marker, although some lineages such as READ and SCLC show a favorable association.

UCS, KIRC, and KICH are the cancer types where LIN28A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	III,IV	0.379	0.798	.005	56	view →
KIRC	DFS	Median	II,III,IV	0.422	0.597	.001	48	view →
KICH	OS	Tertile	All	0.485	0.952	.003	48	view →
BRCA	OS	Quartile	All	0.486	0.630	.006	34	view →
DLBC	DFS	Tertile	II,III,IV	0.200	1.000	.006	25	view →
LIHC	OS	Quartile	II,III,IV	0.249	0.498	.003	23	view →
READ	OS	Quartile	All	1.000	0.616	.014	21	view →
CHOL	DFS	Median	All	0.118	0.573	.008	18	view →
SCLC	OS	Quartile	All	0.634	0.284	.002	13	view →
THYM	OS	Tertile	III,IV	0.610	1.000	.024	12	view →
COAD	DFS	Tertile	IV	0.754	0.340	.018	9	view →
PCPG	OS	Tertile	All	0.786	1.000	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

LIN28A–UCS (OS)

Open the UCS breakdown →