LIN28A

Across TCGA patient cohorts, LIN28A protein abundance is significantly associated with the RNA expression of many other genes, with 675 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible LIN28A-associated genes across cancer lineages are BMP7, FAM83D, and PRMT8. Each is linked with LIN28A in more than 1 cancer types. Because this analysis shows association rather than direction, both LIN28A-to-partner and partner-to-LIN28A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LIN28A versus BMP7 in PDAC, with a Pearson correlation of -0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN28A→partner) and Y-score (partner→LIN28A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	BMP7 →	-0.910	-1.337	.001	.001	3	1
PDAC	FAM83D →	-0.844	-1.097	.002	.004	3	1
PDAC	PRMT8 →	+0.069	+0.803	.004	.006	3	1
PDAC	FANCE →	-0.447	-1.158	.001	.006	3	1
PDAC	ECHS1 →	-0.497	-1.140	.004	.004	3	1
PDAC	PLCB2 →	-0.485	-0.938	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 675 associations by consensus.

LIN28A vs BMP7 — PDAC

Explore this scatter interactively →