LIN28A

Across TCGA patient cohorts, LIN28A protein abundance is significantly associated with the protein abundance of many other proteins, with 2,189 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible LIN28A-associated proteins across cancer lineages are ARL2BP_S141, BPTF_T739, and CD72. Each is linked with LIN28A in more than 1 cancer types. Because this analysis shows association rather than direction, both LIN28A-to-partner and partner-to-LIN28A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LIN28A versus ARL2BP_S141 in CCRCC, with a Pearson correlation of 0.82.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN28A→partner) and Y-score (partner→LIN28A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ARL2BP_S141 →	+1.330	+0.413	<.001	<.001	3	1
BRCA	BPTF_T739 →	-0.556	-1.104	.005	.005	3	1
BRCA	CD72 →	+0.816	+1.351	<.001	.001	3	1
BRCA	EFL1 →	-0.350	-1.921	<.001	<.001	3	1
BRCA	GON7 →	-0.263	-1.249	.001	<.001	3	1
BRCA	ICAM3 →	+0.870	+1.622	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,189 associations by consensus.

LIN28A vs ARL2BP_S141 — CCRCC

Explore this scatter interactively →