LIN28A

Across TCGA cell cohorts, LIN28A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,009 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LIN28A-associated GO terms across cancer lineages are Peptidyl-proline hydroxylation, Positive regulation of double-strand break repair, and Regulation of vacuole organization. Each is linked with LIN28A in more than 4 cancer types. Because this analysis shows association rather than direction, both LIN28A-to-partner and partner-to-LIN28A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-proline hydroxylation grouped by LIN28A-low versus LIN28A-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LIN28A→partner) and Y-score (partner→LIN28A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Peptidyl-proline hydroxylation →	+0.096	+1.866	.002	.001	3	5
BLOOD_Leukemia	Positive regulation of double-strand break repair →	+0.044	+0.036	.006	.009	3	5
BLOOD_Lymphoma	Regulation of vacuole organization →	+0.042	+0.020	.001	.007	3	5
BLOOD_Lymphoma	RNA surveillance →	+0.041	+0.016	.005	.006	3	5
SKIN	Potassium ion transmembrane transport →	-0.051	-0.024	.008	<.001	3	5
PANCREAS	Glycophagy →	+0.085	+0.034	.006	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,009 associations by consensus.

Peptidyl-proline hydroxylation by LIN28A expression — SOFT_TISSUE

Explore this box plot interactively →