LIMS3

Across TCGA patient cohorts, LIMS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,447 significant associations in total. STAD shows the largest number of these associations.

The most reproducible LIMS3-associated GO terms across cancer lineages are SMAD protein signal transduction, Smooth muscle cell migration, and Ovulation. Each is linked with LIMS3 in more than 3 cancer types. Because this analysis shows association rather than direction, both LIMS3-to-partner and partner-to-LIMS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMAD protein signal transduction grouped by LIMS3-low versus LIMS3-high in SKCM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMS3→partner) and Y-score (partner→LIMS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SMAD protein signal transduction →	+0.040	+0.002	<.001	<.001	3	4
STAD	Smooth muscle cell migration →	+0.050	+0.025	<.001	<.001	3	4
PCPG	Ovulation →	+0.079	+0.005	<.001	.002	3	3
STAD	Osteoblast differentiation →	+0.033	+0.022	<.001	<.001	3	3
STAD	Endothelial cell proliferation →	+0.045	+0.026	<.001	<.001	3	3
STAD	Blood vessel remodeling →	+0.036	+0.020	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,447 associations by consensus.

SMAD protein signal transduction by LIMS3 expression — SKCM

Explore this box plot interactively →