LIMS3

Across TCGA cell cohorts, LIMS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,853 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LIMS3-associated GO terms across cancer lineages are Response to starvation, Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, and Peptidyl-serine phosphorylation. Each is linked with LIMS3 in more than 9 cancer types. Because this analysis shows association rather than direction, both LIMS3-to-partner and partner-to-LIMS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to starvation grouped by LIMS3-low versus LIMS3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMS3→partner) and Y-score (partner→LIMS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Response to starvation →	+0.051	+0.685	.001	.009	2	10
BONE	Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.137	+1.100	.001	.003	3	8
UPPER_AERODIGESTIVE_TRACT	Peptidyl-serine phosphorylation →	+0.079	+1.180	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Peptidyl-serine modification →	+0.075	+1.090	.001	.001	3	7
SOFT_TISSUE	Response to dehydroepiandrosterone →	+0.146	+1.309	<.001	<.001	3	7
LARGE_INTESTINE	Response to platelet-derived growth factor →	+0.101	+0.883	<.001	.009	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,853 associations by consensus.

Response to starvation by LIMS3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →