LIMK1

Across TCGA patient cohorts, LIMK1 mutation is significantly associated with the RNA expression of many other genes, with 3,711 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIMK1-associated genes across cancer lineages are RNU7-80P, PRAMEF14, and ARL2BPP1. Each is linked with LIMK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LIMK1-to-partner and partner-to-LIMK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-80P grouped by LIMK1-low versus LIMK1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMK1→partner) and Y-score (partner→LIMK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU7-80P →	+0.414	+4.505	<.001	.009	3	3
LGG	PRAMEF14 →	+0.035	+5.679	<.001	.003	3	2
LGG	ARL2BPP1 →	+0.091	+5.266	<.001	.006	3	2
LGG	SIGLEC21P →	+0.077	+5.936	<.001	.002	3	2
LGG	FAM25C →	+0.230	+6.363	<.001	.001	3	2
CESC	MIR7-3 →	+0.152	+4.020	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,711 associations by consensus.

RNU7-80P by LIMK1 expression — HNSC

Explore this box plot interactively →