LIMCH1

Across TCGA cell cohorts, LIMCH1 mutation is significantly associated with the RNA expression of many other genes, with 1,327 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LIMCH1-associated genes across cancer lineages are C1QTNF2, FAM110C, and ZPBP. Each is linked with LIMCH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LIMCH1-to-partner and partner-to-LIMCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QTNF2 grouped by LIMCH1-low versus LIMCH1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMCH1→partner) and Y-score (partner→LIMCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C1QTNF2 →	+0.037	+3.700	.009	.003	3	2
BLOOD_Leukemia	FAM110C →	+0.636	+3.257	.008	.009	3	2
OVARY	ZPBP →	+0.059	+3.444	<.001	.003	3	2
CNS	UCMA →	+0.165	+4.169	<.001	.008	3	2
LARGE_INTESTINE	TBC1D15 →	+0.573	+3.588	.003	<.001	3	2
LARGE_INTESTINE	NCAN →	+0.118	+2.266	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,327 associations by consensus.

C1QTNF2 by LIMCH1 expression — BLOOD_Leukemia

Explore this box plot interactively →