LIM2

Across TCGA cell cohorts, LIM2 mutation is significantly associated with the mutation status of many other genes, with 475 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LIM2-associated genes across cancer lineages are MRC2, CEP68, and MTREX. Each is linked with LIM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIM2-to-partner and partner-to-LIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRC2 grouped by LIM2-low versus LIM2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIM2→partner) and Y-score (partner→LIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MRC2 →	+3.753	+5.347	<.001	<.001	1	2
BLOOD_Leukemia	CEP68 →	+4.560	+4.309	.007	.007	1	2
BLOOD_Leukemia	MTREX →	+4.560	+4.309	.007	.007	1	2
BLOOD_Leukemia	FKBP4 →	+4.560	+4.309	.007	.007	1	2
BLOOD_Leukemia	GLI2 →	+2.238	+4.044	.005	.005	1	2
LUNG_NSCLC_LUAD	PLD1 →	+4.339	+4.339	.009	.009	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 475 associations by consensus.

MRC2 by LIM2 expression — BLOOD_Leukemia

Explore this box plot interactively →