LIM2

Across TCGA pan-cancer cohorts, LIM2 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of LIM2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LIM2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LIM2 is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

KIRC, LUAD, and BRCA are the cancer types where LIM2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LIM2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.127	<.001	11	view →
LUAD	Female	III,IV	−0.490	<.001	8	view →
BRCA	All	II,III,IV	−0.038	.004	6	view →
LUSC	All	All	−0.160	<.001	4	view →
HNSC	All	All	+0.465	.016	2	view →
KICH	Male	All	+0.047	.043	1	view →
KIRP	All	All	+0.038	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

LIM2–KIRC

Open the KIRC breakdown →