LIG4

Across TCGA cell cohorts, LIG4 mutation is significantly associated with the RNA expression of many other genes, with 92 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LIG4-associated genes across cancer lineages are RFX4, OR7E24, and KRTAP5-4. Each is linked with LIG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIG4-to-partner and partner-to-LIG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFX4 grouped by LIG4-low versus LIG4-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG4→partner) and Y-score (partner→LIG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RFX4 →	+0.065	+3.523	.002	.009	3	2
SOFT_TISSUE	OR7E24 →	+0.029	+5.369	<.001	.004	3	1
SOFT_TISSUE	KRTAP5-4 →	+0.032	+5.369	<.001	.004	3	1
SKIN	PRLHR →	+0.012	+4.437	<.001	.004	3	1
SKIN	OR13D1 →	+0.030	+3.930	<.001	.003	3	1
SKIN	RBMY1E →	+0.163	+4.562	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

RFX4 by LIG4 expression — STOMACH

Explore this box plot interactively →