LIG1

Across TCGA patient cohorts, LIG1 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,209 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LIG1-associated proteins across cancer lineages are MCM3, MCM4, and MCM5. Each is linked with LIG1 in more than 9 cancer types. Because this analysis shows association rather than direction, both LIG1-to-partner and partner-to-LIG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LIG1 versus MCM3 in OV, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG1→partner) and Y-score (partner→LIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MCM3 →	+0.799	+0.747	<.001	<.001	3	10
LUAD	MCM4 →	+0.786	+0.591	<.001	<.001	3	10
LUAD	MCM5 →	+0.752	+0.591	<.001	<.001	3	10
LUAD	MCM6 →	+0.767	+0.591	<.001	<.001	3	10
LUAD	MCM7 →	+0.755	+0.591	<.001	<.001	3	10
LUAD	ATAD2 →	+0.433	+0.408	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,209 associations by consensus.

LIG1 vs MCM3 — OV

Explore this scatter interactively →