LIF

Across TCGA patient cohorts, LIF RNA expression is significantly associated with the protein abundance of many other proteins, with 16,369 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LIF-associated proteins across cancer lineages are JUNB, MNDA, and ELANE. Each is linked with LIF in more than 7 cancer types. Because this analysis shows association rather than direction, both LIF-to-partner and partner-to-LIF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LIF versus JUNB in GBM, with a Pearson correlation of 0.69.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LIF→partner) and Y-score (partner→LIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	JUNB →	+0.530	+1.778	<.001	<.001	3	8
COAD	MNDA →	+0.835	+0.540	<.001	.001	3	8
COAD	ELANE →	+0.927	+0.616	<.001	<.001	3	8
COAD	MPO →	+1.082	+0.716	<.001	<.001	3	7
GBM	PROS1 →	+0.641	+1.753	<.001	<.001	3	7
UCEC	MMP9 →	+0.964	+1.773	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,369 associations by consensus.

LIF vs JUNB — GBM

Explore this scatter interactively →