LIF

Across TCGA pan-cancer cohorts, LIF RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of LIF’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LIF RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LIF is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

COAD, STAD, and KICH are the cancer types where LIF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LIF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+1.804	<.001	11	view →
STAD	Male	II,III,IV	+2.542	<.001	10	view →
KICH	All	II,III,IV	−3.686	<.001	8	view →
LUAD	Female	III,IV	+1.960	<.001	6	view →
BRCA	Female	II,III,IV	−1.042	<.001	6	view →
HNSC	All	All	+0.958	.003	6	view →
READ	All	II,III,IV	+2.474	<.001	5	view →
THCA	Male	All	+1.009	<.001	5	view →
CHOL	Male	All	+3.425	<.001	2	view →
ESCA	All	All	+2.372	.001	2	view →
BLCA	All	All	−1.279	.016	2	view →
KIRC	Male	All	+0.943	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

LIF–COAD

Open the COAD breakdown →