LIF

Across TCGA patient cohorts, LIF protein abundance is significantly associated with the RNA expression of many other genes, with 2,804 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LIF-associated genes across cancer lineages are DENND3, CSF3R, and FPR1. Each is linked with LIF in more than 2 cancer types. Because this analysis shows association rather than direction, both LIF-to-partner and partner-to-LIF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LIF versus DENND3 in LSCC, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIF→partner) and Y-score (partner→LIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DENND3 →	+1.086	+0.899	<.001	<.001	3	3
LSCC	CSF3R →	+1.968	+0.773	<.001	<.001	3	3
UCEC	FPR1 →	+1.657	+0.717	.001	.002	3	3
UCEC	PLAUR →	+1.387	+0.658	.001	.006	3	2
UCEC	C3 →	+3.466	+0.857	<.001	.001	2	3
UCEC	ALOX5AP →	+1.564	+0.760	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,804 associations by consensus.

LIF vs DENND3 — LSCC

Explore this scatter interactively →