LIF

Across TCGA patient cohorts, LIF mutation is significantly associated with the RNA expression of many other genes, with 1,401 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIF-associated genes across cancer lineages are RN7SL93P, LINC02559, and RNA5SP411. Each is linked with LIF in more than 2 cancer types. Because this analysis shows association rather than direction, both LIF-to-partner and partner-to-LIF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL93P grouped by LIF-low versus LIF-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIF→partner) and Y-score (partner→LIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL93P →	+0.087	+4.984	<.001	.003	3	3
CESC	LINC02559 →	+1.058	+4.757	<.001	.004	3	2
UCEC	RNA5SP411 →	+1.094	+2.071	<.001	.003	3	2
UCEC	MIR6857 →	+0.213	+2.551	.008	.007	3	2
CESC	RN7SL134P →	+0.179	+5.289	<.001	<.001	3	2
UCEC	RNU6-366P →	+0.153	+2.904	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,401 associations by consensus.

RN7SL93P by LIF expression — CESC

Explore this box plot interactively →