LIF

Across TCGA patient cohorts, LIF mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIF-associated genes across cancer lineages are A-Raf_pS299, GAPDH, and GATA6. Each is linked with LIF in more than 1 cancer types. Because this analysis shows association rather than direction, both LIF-to-partner and partner-to-LIF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by LIF-low versus LIF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIF→partner) and Y-score (partner→LIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.143	-3.000	.010	.036	3	1
UCEC	GAPDH →	+0.614	+3.321	.014	.009	3	1
UCEC	GATA6 →	-0.193	-3.693	.007	.001	3	1
UCEC	Heregulin →	-0.136	-3.156	.017	.018	3	1
UCEC	Ku80 →	+0.234	+1.887	.033	.031	3	1
UCEC	p27_pT198 →	+0.133	+3.169	.007	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

A-Raf_pS299 by LIF expression — UCEC

Explore this box plot interactively →