LIF

Across TCGA cell cohorts, LIF RNA expression is significantly associated with the go_rna of many other GO terms, with 5,847 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LIF-associated GO terms across cancer lineages are Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis, Leukemia inhibitory factor signaling pathway, and Stem cell division. Each is linked with LIF in more than 18 cancer types. Because this analysis shows association rather than direction, both LIF-to-partner and partner-to-LIF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis grouped by LIF-low versus LIF-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LIF→partner) and Y-score (partner→LIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis →	+1.923	+3.070	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Leukemia inhibitory factor signaling pathway →	+0.297	+3.042	<.001	<.001	3	16
LIVER	Stem cell division →	+0.187	+2.235	<.001	<.001	3	14
SOFT_TISSUE	Regulation of CD4-positive, alpha-beta T cell activation →	+0.090	+2.306	<.001	.001	2	15
SKIN	Positive regulation of myeloid leukocyte differentiation →	+0.153	+2.882	<.001	<.001	3	14
SKIN	Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis →	+0.327	+2.240	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,847 associations by consensus.

Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis by LIF expression — LIVER

Explore this box plot interactively →