LIF

Across TCGA cell cohorts, LIF mutation is significantly associated with the RNA expression of many other genes, with 1 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LIF-associated genes across cancer lineages are OR4N4. Each is linked with LIF in more than 1 cancer types. Because this analysis shows association rather than direction, both LIF-to-partner and partner-to-LIF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4N4 grouped by LIF-low versus LIF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIF→partner) and Y-score (partner→LIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4N4 →	+0.036	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 1 strongest of 1 associations by consensus.

OR4N4 by LIF expression — LARGE_INTESTINE

Explore this box plot interactively →