LHX9

Across TCGA patient cohorts, LHX9 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHX9-associated genes across cancer lineages are JNK_pT183_Y185, MSH2, and p53. Each is linked with LHX9 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHX9-to-partner and partner-to-LHX9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by LHX9-low versus LHX9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX9→partner) and Y-score (partner→LHX9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.178	-1.925	.001	.004	3	2
UCEC	MSH2 →	-0.325	-4.061	<.001	<.001	3	2
UCEC	p53 →	-0.296	-2.584	.018	.010	3	2
UCEC	PDCD4 →	-0.407	-2.459	.007	.018	3	2
UCEC	Annexin-1 →	+0.396	+1.604	.020	.021	3	2
UCEC	Shc_pY317 →	-0.199	-2.247	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

JNK_pT183_Y185 by LHX9 expression — UCEC

Explore this box plot interactively →