LHX9

Across TCGA pan-cancer cohorts, LHX9 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated LHX9 data layer compared with 10 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LHX9 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LHX9 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

UCEC, KIRC, and ACC are the cancer types where LHX9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.782	0.893	<.001	136	view →
KIRC	OS	Tertile	All	0.741	0.868	<.001	124	view →
ACC	DFS	Tertile	All	0.180	0.717	<.001	117	view →
HNSC	OS	Quartile	IV	0.875	0.429	.001	65	view →
MESO	OS	Tertile	All	0.303	0.565	.001	60	view →
SARC	OS	Quartile	All	0.425	0.805	<.001	28	view →
KIRP	OS	Tertile	III,IV	0.236	0.750	.016	27	view →
READ	OS	Quartile	III,IV	0.287	0.869	.004	24	view →
STAD	OS	Quartile	All	0.614	0.731	.016	22	view →
THYM	DFS	Tertile	All	0.293	0.881	.005	22	view →
UCS	DFS	Tertile	All	0.445	0.127	.016	20	view →
SKCM	OS	Quartile	III,IV	0.781	0.562	.003	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

LHX9–UCEC (DFS)

Open the UCEC breakdown →