LHX9

Across TCGA cell cohorts, LHX9 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LHX9-associated genes across cancer lineages are PIH1D1, SH3GL2, and ZFPL1. Each is linked with LHX9 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHX9-to-partner and partner-to-LHX9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIH1D1 grouped by LHX9-low versus LHX9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX9→partner) and Y-score (partner→LHX9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PIH1D1 →	+0.576	+3.212	.002	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+1.364	+3.474	<.001	.003	3	1
LARGE_INTESTINE	ZFPL1 →	+0.467	+3.212	.009	.006	3	1
LARGE_INTESTINE	LZIC →	+0.533	+3.212	.006	.006	3	1
LARGE_INTESTINE	ELP5 →	+0.781	+3.212	.001	.006	3	1
LARGE_INTESTINE	C5orf60 →	+0.098	+3.299	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

PIH1D1 by LHX9 expression — LARGE_INTESTINE

Explore this box plot interactively →