LHX6

Across TCGA patient cohorts, LHX6 mutation is significantly associated with the RNA expression of many other genes, with 1,292 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHX6-associated genes across cancer lineages are ZNF271P, SRCIN1, and TRGV6. Each is linked with LHX6 in more than 2 cancer types. Because this analysis shows association rather than direction, both LHX6-to-partner and partner-to-LHX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF271P grouped by LHX6-low versus LHX6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX6→partner) and Y-score (partner→LHX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF271P →	+0.358	+2.403	.006	<.001	3	3
UCEC	SRCIN1 →	-0.693	-2.898	<.001	.001	3	2
CESC	TRGV6 →	+0.250	+2.906	.005	.007	3	2
CESC	FKBP4P7 →	+0.025	+3.027	<.001	.004	3	2
CESC	LINC00534 →	+0.775	+4.117	<.001	<.001	3	2
UCEC	PTP4A3 →	-0.855	-2.896	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,292 associations by consensus.

ZNF271P by LHX6 expression — UCEC

Explore this box plot interactively →